Pure Actives Co.

L-Glutathione Reduced Powder Canada

$20.00 CAD

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Description

L-Glutathione Reduced Powder

Glutathione – The Master Antioxidant for Advanced Skincare

INCI Name: Glutathione
CAS Number: 70-18-8

Technical Profile
Glutathione is a naturally occurring tripeptide built from glutamic acid, cysteine, and glycine. In biological systems, it acts as the body’s most powerful intracellular antioxidant, controlling redox balance, detoxification, and cellular repair. In cosmetic science, this translates to an active that can intervene in both oxidative stress pathways and melanogenesis regulation, making it one of the few ingredients that offers dual antioxidant and brightening performance.

Why It Matters in Formulations

Pigmentation Modulation: Glutathione directly influences the activity of tyrosinase, the key enzyme in melanin synthesis. By shifting melanogenesis towards pheomelanin (lighter pigment) rather than eumelanin (darker pigment), it helps create a visibly brighter, more uniform complexion.
Oxidative Defense: Beyond pigmentation, Glutathione scavenges reactive oxygen species (ROS) generated by UV radiation, pollution, and inflammation — protecting skin proteins, lipids, and DNA from visible degradation.
Synergistic Antioxidant Recycling: It has the rare ability to regenerate oxidized Vitamin C and Vitamin E, extending the lifespan of these antioxidants within a formulation and amplifying their effects.
Barrier Support: Its role in detoxification pathways contributes to healthier skin resilience, reducing the look of dullness, sallowness, and uneven tone over time.

Unique Value for Cosmetic Developers
Unlike single-pathway brighteners (e.g., kojic acid or arbutin), Glutathione operates on multiple cellular levels — antioxidant defense, enzyme modulation, and pigment balance. This makes it a cornerstone ingredient for high-performance brightening serums, multi-antioxidant complexes, and luxury anti-aging systems.

Formulation Notes

Appearance: White crystalline powder
Solubility: Water-soluble
Processing: Add during cool-down phase (<40 °C) to preserve bioactivity
Compatibility: Works synergistically with Vitamin C, Alpha Arbutin, Niacinamide, and Tranexamic Acid for multi-mechanism pigment control.
Suggested Use Levels: 0.1–2.0% in finished formulations (depending on system design)

Applications

Advanced brightening serums
Intensive anti-aging creams
Post-inflammatory hyperpigmentation (PIH) support products
Antioxidant boosters in daily moisturizers.

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Suggested Usage & Formulation

Glutathione can be dissolved directly into the water phase of serums, emulsions, or gel formulations. It is best added at cool-down once the formulation has dropped below 40 °C. For synergistic effects, it is commonly paired with cosmetic actives such as alpha arbutin, kojic acid, vitamin C derivatives, or niacinamide to support brightening and antioxidant activity. Always check pH and stability in the final formula to maximize performance.

Benefits

Reduced L-Glutathione is known in cosmetics for its antioxidant properties, helping protect skin against external stress factors. It supports a more luminous, balanced-looking complexion while contributing to the overall effectiveness of brightening and anti-aging blends.

Safety

This ingredient is for external use only. Always formulate within recommended use levels and conduct patch testing on finished products before regular use. It is not intended for ingestion or pharmaceutical applications.

Technical Data

Reduced L-Glutathione is a fine white to off-white crystalline powder with a slightly sulfuric odor. It is water-soluble and should be incorporated into the aqueous phase or during the cool-down stage of formulation at temperatures below 40 °C to preserve stability. Typical cosmetic use levels range from 0.1% to 2%. It is most stable in formulations with a pH between 5.0 and 7.0. Store in a tightly sealed container at 2–8 °C in a cool, dry environment, away from direct sunlight and humidity. Under proper conditions, shelf life is approximately 24 months.