D-Panthenol Liquid 100% (Provitamin B5) — Cosmetic Grade

D-Panthenol Liquid 100% (Provitamin B5) — Cosmetic Grade Hydrating & Repairing Active

D-Panthenol is the biologically active D-isomer of panthenol and the direct precursor to pantothenic acid (Vitamin B5). Once absorbed into skin or hair, it is oxidized to pantothenic acid and integrated into coenzyme A — a critical cofactor in fatty acid synthesis and cellular repair. This product is 100% pure D-Panthenol — a thick, clear, viscous liquid at room temperature, with no added water or carrier.

Clinically validated across decades of cosmetic and dermatological research, D-Panthenol is a cornerstone active in professional skincare and haircare formulations worldwide. It is gentle enough for sensitive and compromised skin, effective at low concentrations, and compatible with virtually every formulation system.

D-Panthenol vs. DL-Panthenol — Why It Matters

There are two forms of panthenol on the market and the difference is significant:

• D-Panthenol (this product) — CAS 81-13-0 — the pure D-isomer; the only form biologically active in human skin and hair. A thick, viscous liquid at 100% concentration. Converts directly to D-pantothenic acid in the body. Premium cosmetic grade.
• DL-Panthenol — CAS 16485-10-2 — a racemic 50/50 mixture of D and L isomers. The L-isomer has no known biological activity in skin. Sold as a 100% pure crystalline powder — solid at room temperature. Cost-effective and widely used. Available as our DL-Panthenol Powder.

Bottom line: 1g of this 100% D-Panthenol delivers twice the active D-isomer of 1g of DL-Panthenol powder. For formulators who prioritize maximum efficacy per gram, pure D-Panthenol liquid is the superior choice.

Key Benefits

• Deep, lasting hydration — humectant that attracts and binds water in the stratum corneum; measurably improves skin moisture content at concentrations as low as 1%
• Barrier repair & wound healing — stimulates keratinocyte proliferation and fibroblast activity; accelerates re-epithelialization and barrier recovery in compromised, dry, or post-procedure skin
• Anti-inflammatory & soothing — reduces erythema, irritation, and TEWL; well-documented for sensitive, reactive, and eczema-prone skin
• Hair conditioning & strengthening — penetrates the hair cortex, improves elasticity and tensile strength, reduces brittleness and breakage, adds shine and manageability
• 100% pure — no dilution, no water — maximum active concentration; dose exactly what your formula needs with no hidden water content affecting your water phase calculations
• Ready-to-use liquid — no dissolution required; add directly to water phase or cool-down

How to Use

• Incorporation: Add directly to the water phase or at cool-down (below 40°C). No pre-dissolution required. Being 100% pure and viscous, measure by weight for accuracy
• Recommended Usage Rate: 0.5–5% in finished formulations (1–3% most common; up to 5% in intensive repair or haircare products)
• Solubility: Water-soluble; miscible in water and alcohol-based systems. Being 100% pure, warm water phase (40–60°C) aids mixing
• pH Compatibility: Stable across pH 4.0–8.0
• Processing temperature: Do not exceed 70°C

Formulation Details

Suggested Formulas & Pairings

D-Panthenol Liquid works synergistically with:

• Hyaluronic Acid — combine with Hyaluronic Acid Powder LMW in the water phase for a multi-mechanism hydration system; HA draws water to the surface while D-Panthenol repairs and seals the barrier
• Niacinamide — pair with Niacinamide Vitamin B3 Powder for a barrier-strengthening, anti-inflammatory serum base; both are water-soluble and fully compatible
• Hydrolyzed Keratin — combine with Hydrolyzed Keratin Protein Powder in haircare for a dual protein-vitamin conditioning system targeting structural repair and moisture retention
• Hydrolyzed Oat Protein — layer with Hydrolyzed Oat Protein Powder for enhanced soothing and film-forming performance in sensitive skin or scalp formulations
• DL-Panthenol Powder — also available as DL-Panthenol Powder for powder-based formulations

Example formula: A 3% D-Panthenol + 2% Niacinamide + 1% Hyaluronic Acid LMW hydrating serum in a water/glycerin base, preserved with 0.8% Euxyl PE 9010, pH adjusted to 5.5. Add D-Panthenol and Niacinamide to warm water phase (50°C); add HA and preservative at cool-down.

Formulation Guide

Explore the full science of panthenol — how it works in skin and hair, clinical evidence for barrier repair and hydration, D vs. DL isomer comparison, and formulation strategies for serums, creams, and haircare.

→ Panthenol for Skin, Hair, and Nails: The Unsung Hero Your Routine Needs

All products sold are cosmetic grade. For external use only. Intended for cosmetic and personal care formulations.