{"product_id":"sepiwhite™-msh-undecylenoyl-phenylalanine","title":"Sepiwhite™ MSH (Undecylenoyl Phenylalanine)","description":"\u003ch1\u003eSepiwhite™ MSH — The Brightening Active That Stops Melanin Before It Starts\u003c\/h1\u003e\n\u003cp\u003eMost brightening ingredients fight melanin \u003cem\u003eafter\u003c\/em\u003e it’s already being made. \u003cstrong\u003eSepiwhite™ MSH (Undecylenoyl Phenylalanine)\u003c\/strong\u003e goes upstream. As an \u003cstrong\u003eα-MSH antagonist\u003c\/strong\u003e, it blocks the hormonal signal that tells your skin to produce melanin in the first place — giving you a smarter, more targeted approach to fading dark spots, hyperpigmentation, and uneven tone. If you’ve been layering kojic acid and arbutin without the results you want, this is the missing piece.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWho Is This For?\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eDIY formulators building advanced brightening serums, creams, or spot treatments\u003c\/li\u003e\n\u003cli\u003eSkincare brands seeking a unique, upstream mechanism distinct from tyrosinase inhibitors\u003c\/li\u003e\n\u003cli\u003eFormulators targeting melasma, post-inflammatory hyperpigmentation (PIH), or UV-induced dark spots\u003c\/li\u003e\n\u003cli\u003eAnyone wanting to build a true multi-pathway brightening formula by combining Sepiwhite™ MSH with actives like \u003ca href=\"\/products\/8007776632931\"\u003eSymWhite® 377\u003c\/a\u003e, \u003ca href=\"\/products\/7629216153699\"\u003eAlpha Arbutin\u003c\/a\u003e, or \u003ca href=\"\/products\/7629185351779\"\u003eTranexamic Acid\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat It Does For Your Skin\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eFades dark spots and hyperpigmentation by targeting the root hormonal signal\u003c\/li\u003e\n\u003cli\u003eReduces post-inflammatory marks — ideal for acne-prone skin prone to discolouration\u003c\/li\u003e\n\u003cli\u003eEvens skin tone and boosts radiance for a visibly brighter complexion over time\u003c\/li\u003e\n\u003cli\u003eWorks synergistically with tyrosinase inhibitors for multi-pathway pigmentation control\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eThe Science Behind It\u003c\/h2\u003e\n\u003cp\u003eMelanin production is triggered by α-MSH (alpha-melanocyte-stimulating hormone). Sepiwhite™ MSH competes with this hormone at the receptor level — interrupting the signal \u003cem\u003ebefore\u003c\/em\u003e melanin synthesis begins. This mechanism is entirely distinct from tyrosinase inhibitors like kojic acid or alpha arbutin, making it a powerful addition to any brightening formula rather than a replacement.\u003c\/p\u003e\n\u003cp\u003eManufacturer-supported studies show improvements in skin luminosity and pigmentation reduction. Widely respected in the professional formulation community.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eFormulation Details\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eINCI Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUndecylenoyl Phenylalanine\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTrade Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSepiwhite™ MSH\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRecommended Usage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e0.2 – 2%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAppearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWhite powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSolubility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOil, alcohol, or high-pH water systems\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBest Incorporation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHeated oil phase at 70–80°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003epH Compatibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003epH 4–5 or above 6.2 depending on system\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003chr\u003e\n\u003ch2\u003eFormulator Tips\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eDo not add directly to cold water — it will clump and won’t disperse properly\u003c\/li\u003e\n\u003cli\u003ePre-dissolve in warm oil, propanediol, ethanol, or glycols before emulsification\u003c\/li\u003e\n\u003cli\u003eIncorporate during the heated oil phase for best solubilization\u003c\/li\u003e\n\u003cli\u003eAlways check pH compatibility with your full formula before finalizing\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eBest Ingredient Pairings\u003c\/h2\u003e\n\u003cp\u003eSepiwhite™ MSH shines brightest in multi-active formulas. Combine it with these ingredients to hit pigmentation from every angle:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/products\/8007776632931\"\u003eSymWhite® 377 (Phenethyl Resorcinol)\u003c\/a\u003e\u003c\/strong\u003e — dual-pathway tyrosinase + DHICA oxidase inhibitor\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/products\/7903971868771\"\u003eNiacinamide\u003c\/a\u003e\u003c\/strong\u003e — inhibits pigment transfer to skin cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/products\/7629185351779\"\u003eTranexamic Acid\u003c\/a\u003e\u003c\/strong\u003e — reduces UV-triggered melanin stimulation\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/products\/7629216153699\"\u003eAlpha Arbutin\u003c\/a\u003e\u003c\/strong\u003e — tyrosinase inhibition for complementary action\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/products\/7903971901539\"\u003eN-Acetyl Glucosamine (NAG)\u003c\/a\u003e\u003c\/strong\u003e — reduces melanin synthesis and improves texture\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitamin C derivatives\u003c\/strong\u003e — antioxidant protection and brightening boost\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eFull Clinical Brightening Serum Formula (100%)\u003c\/h2\u003e\n\u003cp\u003eA high-performance, multi-pathway brightening serum targeting melanin signaling, pigment transfer, tyrosinase activity, and barrier repair simultaneously. This formula is designed to be layered under SPF for daytime use or used as a standalone treatment serum.\u003c\/p\u003e\n\n\u003ch3\u003ePhase A — Water Phase\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003e%\u003c\/th\u003e\n\u003cth\u003eRole\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eDistilled Water (Aqua)\u003c\/td\u003e\n\u003ctd\u003eto 100%\u003c\/td\u003e\n\u003ctd\u003eSolvent base\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlycerin\u003c\/td\u003e\n\u003ctd\u003e4.0%\u003c\/td\u003e\n\u003ctd\u003eHumectant, skin conditioning\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/products\/7629132824675\"\u003eSodium Hyaluronate (LMW)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e0.5%\u003c\/td\u003e\n\u003ctd\u003eDeep hydration, barrier support\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/products\/7903971868771\"\u003eNiacinamide (Vitamin B3)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e5.0%\u003c\/td\u003e\n\u003ctd\u003eBlocks melanosome transfer, anti-inflammatory\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/products\/7629185351779\"\u003eTranexamic Acid\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e3.0%\u003c\/td\u003e\n\u003ctd\u003eInhibits UV-induced melanin stimulation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/products\/7629216153699\"\u003eAlpha Arbutin\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e1.0%\u003c\/td\u003e\n\u003ctd\u003eTyrosinase inhibitor, brightening synergy\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/products\/7903971901539\"\u003eN-Acetyl Glucosamine (NAG)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e2.0%\u003c\/td\u003e\n\u003ctd\u003eReduces melanin synthesis, improves skin texture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003ePhase B — Heated Oil Phase (70–80°C)\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003e%\u003c\/th\u003e\n\u003cth\u003eRole\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003ePropanediol or light emollient (e.g. Squalane)\u003c\/td\u003e\n\u003ctd\u003e3.0%\u003c\/td\u003e\n\u003ctd\u003eCarrier for Sepiwhite™ MSH, skin-feel enhancer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSepiwhite™ MSH (Undecylenoyl Phenylalanine)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1.0%\u003c\/td\u003e\n\u003ctd\u003eα-MSH antagonist — blocks melanin signaling at the receptor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003ePhase C — Cool-Down Actives (add below 40°C)\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003e%\u003c\/th\u003e\n\u003cth\u003eRole\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/products\/7946667556963\"\u003eD-Panthenol (Provitamin B5)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e2.0%\u003c\/td\u003e\n\u003ctd\u003eBarrier repair, soothing, anti-inflammatory\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/products\/7902377312355\"\u003eAllantoin Powder\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e0.2%\u003c\/td\u003e\n\u003ctd\u003eSkin-soothing, cell renewal support\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/products\/7946666967139\"\u003eGermall Plus\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e0.5%\u003c\/td\u003e\n\u003ctd\u003eBroad-spectrum preservation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003ePhase D — pH Adjustment\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003e%\u003c\/th\u003e\n\u003cth\u003eRole\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eSodium Hydroxide (10% solution) or Citric Acid\u003c\/td\u003e\n\u003ctd\u003eq.s.\u003c\/td\u003e\n\u003ctd\u003eAdjust to target pH for stability and skin compatibility\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003cp\u003e\u003cstrong\u003eTarget pH:\u003c\/strong\u003e 4.5–5.5  |  \u003cstrong\u003eTarget Viscosity:\u003c\/strong\u003e Light-to-medium serum (add Hydroxyethylcellulose at 0.3–0.5% in Phase A if thickening is desired)\u003c\/p\u003e\n\n\u003ch3\u003eFormulation Notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eIncorporate Sepiwhite™ MSH into the heated oil\/solvent phase at 70–80°C — do not add to cold water\u003c\/li\u003e\n\u003cli\u003eNiacinamide, Tranexamic Acid, Alpha Arbutin, and NAG are all water-soluble and heat-stable — safe to add in Phase A\u003c\/li\u003e\n\u003cli\u003eAdd D-Panthenol and Allantoin in cool-down to preserve their activity\u003c\/li\u003e\n\u003cli\u003eCheck pH after cool-down and adjust before adding preservative\u003c\/li\u003e\n\u003cli\u003eConduct a 3-month stability test (40°C\/75% RH) and patch test before commercializing\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cem\u003eSold as a cosmetic raw material for professional formulation use. Not intended for direct skin application. Always conduct safety and stability testing before commercializing finished products.\u003c\/em\u003e\u003c\/p\u003e","brand":"PURE ACTIVES","offers":[{"title":"10 g","offer_id":44167517896803,"sku":"SEPIWHITE-10G-1","price":16.99,"currency_code":"CAD","in_stock":true},{"title":"25 g","offer_id":44167517929571,"sku":"SEPIWHITE-10G-2","price":39.99,"currency_code":"CAD","in_stock":true},{"title":"50 g","offer_id":44167517962339,"sku":"SEPIWHITE-10G-3","price":74.99,"currency_code":"CAD","in_stock":true},{"title":"100 g","offer_id":44167517995107,"sku":"SEPIWHITE-10G-4","price":139.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0598\/4154\/4291\/files\/ChatGPTImageMay7_2026_09_06_17AM.png?v=1778170547","url":"https:\/\/www.pureactivesco.ca\/products\/sepiwhite%e2%84%a2-msh-undecylenoyl-phenylalanine","provider":"PURE ACTIVES","version":"1.0","type":"link"}