{"product_id":"symwhite®-377-phenethyl-resorcinol-advanced-skin-brightening-active","title":"SymWhite® 377 (Phenethyl Resorcinol) – Advanced Skin Brightening Active","description":"\u003ch1\u003eSymWhite® 377 — The New Gold Standard for Hyperpigmentation\u003c\/h1\u003e\n\u003cp\u003eDark spots, uneven skin tone, post-acne marks, melasma — these are some of the most searched skin concerns in DIY skincare. \u003cstrong\u003eSymWhite® 377 (Phenethyl Resorcinol)\u003c\/strong\u003e is the clinically validated brightening active that professional formulators reach for when they need results without irritation. If you're building a brightening serum, spot treatment, or intimate care formula, this is the ingredient to anchor it.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWho Is This For?\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eDIY formulators targeting hyperpigmentation, dark spots, or uneven skin tone\u003c\/li\u003e\n\u003cli\u003eSkincare brands looking for a hydroquinone-free, clinically backed brightening active\u003c\/li\u003e\n\u003cli\u003eFormulators working on sensitive skin, intimate brightening, or post-inflammatory pigmentation (PIH) products\u003c\/li\u003e\n\u003cli\u003eAnyone who wants a tyrosinase inhibitor with antioxidant and anti-inflammatory benefits built in\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat Is SymWhite® 377?\u003c\/h2\u003e\n\u003cp\u003eSymWhite 377 is a skin brightening active with the INCI name \u003cstrong\u003ePhenethyl Resorcinol\u003c\/strong\u003e. It works by inhibiting \u003cstrong\u003etyrosinase\u003c\/strong\u003e — the enzyme responsible for triggering melanin production in the skin. Less melanin activity means fewer dark spots, more even tone, and a visibly brighter complexion over time.\u003c\/p\u003e\n\u003cp\u003eWhat makes SymWhite 377 stand out is that it doesn’t stop at tyrosinase. It also inhibits \u003cstrong\u003eDHICA oxidase\u003c\/strong\u003e, a second enzyme in the melanin pathway — giving it a broader, more effective mechanism than most brightening ingredients on the market.\u003c\/p\u003e\n\u003cp\u003eOn top of that, it carries \u003cstrong\u003eantioxidant and anti-inflammatory properties\u003c\/strong\u003e that help protect skin from the environmental triggers that cause pigmentation in the first place.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat the Clinical Studies Say\u003c\/h2\u003e\n\u003cp\u003eThis isn’t marketing language — it’s science.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA study in the \u003cem\u003eJournal of Cosmetic Dermatology\u003c\/em\u003e tested SymWhite 377 on 30 healthy female volunteers. After 12 weeks, it \u003cstrong\u003esignificantly reduced hyperpigmentation\u003c\/strong\u003e and improved skin lightness and evenness.\u003c\/li\u003e\n\u003cli\u003eA study in the \u003cem\u003eJournal of Drugs in Dermatology\u003c\/em\u003e tested a SymWhite 377 serum on 28 subjects with facial hyperpigmentation. Results: \u003cstrong\u003eeffective reduction in dark spots with no irritation or adverse effects.\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eA safety assessment in the \u003cem\u003eInternational Journal of Toxicology\u003c\/em\u003e confirmed SymWhite 377 is \u003cstrong\u003enon-genotoxic, non-mutagenic, non-carcinogenic, and not a skin sensitizer\u003c\/strong\u003e — making it one of the safest brightening actives available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eReduces hyperpigmentation and dark spots\u003c\/li\u003e\n\u003cli\u003eEvens out skin tone for a more radiant complexion\u003c\/li\u003e\n\u003cli\u003eFades post-inflammatory marks (including acne scars and PIH)\u003c\/li\u003e\n\u003cli\u003eAntioxidant protection against environmental stressors\u003c\/li\u003e\n\u003cli\u003eSafe and gentle — no irritation, no redness\u003c\/li\u003e\n\u003cli\u003eHydroquinone-free alternative with clinical backing\u003c\/li\u003e\n\u003cli\u003eSuitable for sensitive skin and intimate brightening formulas\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eHow Long Does It Take to Work?\u003c\/h2\u003e\n\u003cp\u003eMost people begin to notice visible improvement within a \u003cstrong\u003efew weeks\u003c\/strong\u003e of consistent use. For best results, continued use over \u003cstrong\u003e8–12 weeks\u003c\/strong\u003e is recommended — consistent with the timelines shown in clinical studies.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eFormulation Details\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eINCI Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePhenethyl Resorcinol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTrade Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSymWhite® 377\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRecommended Usage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e0.1 – 0.5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAppearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWhite to off-white powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSolubility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSoluble in ethanol, propylene glycol, and oils\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBest Incorporation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePre-dissolve in solvent before adding to formula\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003epH Stability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003epH 4–7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003chr\u003e\n\u003ch2\u003eFormulator Tips\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eDo not add directly to water — dissolve in ethanol, propanediol, or a carrier oil first\u003c\/li\u003e\n\u003cli\u003eUse at 0.1–0.5% — highly potent at low concentrations\u003c\/li\u003e\n\u003cli\u003eCombine with antioxidants (Vitamin E, Vitamin C derivatives) to boost stability\u003c\/li\u003e\n\u003cli\u003eWorks beautifully in serums, creams, spot treatments, and intimate brightening formulas\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eBest Ingredient Pairings\u003c\/h2\u003e\n\u003cp\u003eSymWhite 377 performs even better when combined with complementary brightening actives that target different steps of the pigmentation process:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/fr\/products\/7903971868771\"\u003eNiacinamide\u003c\/a\u003e\u003c\/strong\u003e — blocks pigment transfer to skin cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/fr\/products\/7629185351779\"\u003eTranexamic Acid\u003c\/a\u003e\u003c\/strong\u003e — reduces UV-triggered melanin stimulation\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"\/fr\/products\/7629216153699\"\u003eAlpha Arbutin\u003c\/a\u003e\u003c\/strong\u003e — additional tyrosinase inhibition\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKojic Acid\u003c\/strong\u003e — synergistic enzymatic inhibition\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitamin C derivatives\u003c\/strong\u003e — antioxidant brightening boost\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAzelaic Acid\u003c\/strong\u003e — anti-inflammatory pigmentation control\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eFull Clinical Brightening Serum Formula (100%)\u003c\/h2\u003e\n\u003cp\u003eThis is a complete, ready-to-formulate brightening serum targeting hyperpigmentation, dark spots, and uneven tone. Each ingredient is chosen to address a distinct step in the melanin pathway or support skin barrier integrity.\u003c\/p\u003e\n\n\u003ch3\u003ePhase A — Water Phase\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003e%\u003c\/th\u003e\n\u003cth\u003eRole\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eDistilled Water (Aqua)\u003c\/td\u003e\n\u003ctd\u003eto 100%\u003c\/td\u003e\n\u003ctd\u003eSolvent base\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGlycerin\u003c\/td\u003e\n\u003ctd\u003e4.0%\u003c\/td\u003e\n\u003ctd\u003eHumectant, skin conditioning\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/fr\/products\/7629132824675\"\u003eSodium Hyaluronate (LMW)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e0.5%\u003c\/td\u003e\n\u003ctd\u003eDeep hydration, plumping\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/fr\/products\/7903971868771\"\u003eNiacinamide (Vitamin B3)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e4.0%\u003c\/td\u003e\n\u003ctd\u003eBlocks melanosome transfer, anti-inflammatory\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/fr\/products\/7629185351779\"\u003eTranexamic Acid\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e2.0%\u003c\/td\u003e\n\u003ctd\u003eInhibits UV-induced melanin stimulation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/fr\/products\/7629216153699\"\u003eAlpha Arbutin\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e1.0%\u003c\/td\u003e\n\u003ctd\u003eTyrosinase inhibitor, brightening synergy\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003ePhase B — Solvent Pre-Dissolve (Active Phase)\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003e%\u003c\/th\u003e\n\u003cth\u003eRole\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003ePropanediol (or Ethanol)\u003c\/td\u003e\n\u003ctd\u003e3.0%\u003c\/td\u003e\n\u003ctd\u003eSolvent for SymWhite 377, skin-feel enhancer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003e\u003ca href=\"\/fr\/products\/8007776632931\"\u003eSymWhite® 377 (Phenethyl Resorcinol)\u003c\/a\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e0.3%\u003c\/td\u003e\n\u003ctd\u003eDual-pathway tyrosinase + DHICA oxidase inhibitor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003ePhase C — Cool-Down Actives (add below 40°C)\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003e%\u003c\/th\u003e\n\u003cth\u003eRole\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/fr\/products\/7946667556963\"\u003eD-Panthenol (Provitamin B5)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e2.0%\u003c\/td\u003e\n\u003ctd\u003eBarrier repair, soothing, anti-inflammatory\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/fr\/products\/7902377312355\"\u003eAllantoin Powder\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e0.2%\u003c\/td\u003e\n\u003ctd\u003eSkin-soothing, cell renewal support\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003ca href=\"\/fr\/products\/7946666967139\"\u003eGermall Plus\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003e0.5%\u003c\/td\u003e\n\u003ctd\u003eBroad-spectrum preservation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003ePhase D — pH Adjustment\u003c\/h3\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003e%\u003c\/th\u003e\n\u003cth\u003eRole\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eSodium Hydroxide (10% solution) or Citric Acid\u003c\/td\u003e\n\u003ctd\u003eq.s.\u003c\/td\u003e\n\u003ctd\u003eAdjust to pH 5.5–6.0 for stability and skin compatibility\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003cp\u003e\u003cstrong\u003eTarget pH:\u003c\/strong\u003e 5.5–6.0  |  \u003cstrong\u003eTarget Viscosity:\u003c\/strong\u003e Light serum (adjust with Hydroxyethylcellulose or Carbomer at 0.3–0.5% in Phase A if desired)\u003c\/p\u003e\n\n\u003ch3\u003eFormulation Notes\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePre-dissolve SymWhite 377 fully in propanediol before combining with Phase A — it will not dissolve in water alone\u003c\/li\u003e\n\u003cli\u003eAdd Niacinamide and Tranexamic Acid to the water phase while mixing at room temperature\u003c\/li\u003e\n\u003cli\u003eAlpha Arbutin is water-soluble and heat-stable up to 70°C — safe to add in Phase A\u003c\/li\u003e\n\u003cli\u003eAdd D-Panthenol and Allantoin in cool-down to preserve activity\u003c\/li\u003e\n\u003cli\u003eAlways check final pH before preserving — SymWhite 377 is stable at pH 4–7\u003c\/li\u003e\n\u003cli\u003eConduct a 3-month stability test (40°C\/75% RH) and patch test before commercializing\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cem\u003eSold as a cosmetic raw material for professional formulation use. Not intended for direct skin application. Always conduct safety and stability testing before commercializing finished products.\u003c\/em\u003e\u003c\/p\u003e","brand":"PURE ACTIVES","offers":[{"title":"10 g","offer_id":44167600930915,"sku":null,"price":16.99,"currency_code":"CAD","in_stock":true},{"title":"25 g","offer_id":44167600963683,"sku":null,"price":39.99,"currency_code":"CAD","in_stock":true},{"title":"50 g","offer_id":44167600996451,"sku":null,"price":74.99,"currency_code":"CAD","in_stock":true},{"title":"100 g","offer_id":44167601029219,"sku":null,"price":139.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0598\/4154\/4291\/files\/ChatGPTImageMay7_2026_10_05_18AM.png?v=1778173533","url":"https:\/\/www.pureactivesco.ca\/fr\/products\/symwhite%c2%ae-377-phenethyl-resorcinol-advanced-skin-brightening-active","provider":"PURE ACTIVES","version":"1.0","type":"link"}