{"product_id":"hydroxypinacolone-retinoate-hpr-10-liquid","title":"Hydroxypinacolone Retinoate (HPR) 10% Liquid","description":"\u003ch2\u003eHydroxypinacolone Retinoate (HPR) 10% Liquid — Next-Generation Retinoid for Cosmetic Formulations\u003c\/h2\u003e\u003cp\u003eHydroxypinacolone Retinoate (HPR) is a retinoic acid ester — meaning it binds directly to retinoic acid receptors in the skin without requiring enzymatic conversion. Unlike retinol, which must be converted through multiple steps before becoming active, HPR is immediately bioavailable at the receptor level. The result: retinoid-level efficacy with significantly less irritation, making it one of the most formulator-friendly retinoids available today.\u003c\/p\u003e\u003cp\u003eThis 10% concentration in a carrier base gives you a potent, ready-to-dilute active for anti-aging serums, facial oils, and emulsions targeting fine lines, uneven texture, and hyperpigmentation.\u003c\/p\u003e\u003ch3\u003eKey Benefits\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDirect retinoic acid receptor agonist\u003c\/strong\u003e — HPR binds RARα, RARβ, and RARγ receptors directly, delivering retinoid activity without the conversion cascade required by retinol or retinyl esters\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSignificantly lower irritation profile\u003c\/strong\u003e — clinical and formulator data consistently show HPR produces less erythema, peeling, and TEWL disruption than equivalent retinol concentrations\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargets fine lines, texture \u0026amp; pigmentation\u003c\/strong\u003e — stimulates collagen synthesis, accelerates cell turnover, and inhibits MMP activity for visible anti-aging results\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOil-soluble\u003c\/strong\u003e — incorporates cleanly into oil phases, anhydrous serums, and emulsions; does not require solubilizers in oil-based systems\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhotostable\u003c\/strong\u003e — more stable to light and air than retinol; still recommend amber\/opaque packaging and antioxidant co-formulation as best practice\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHow to Use\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIncorporation:\u003c\/strong\u003e Add to the oil phase or cool-down phase (below 40°C \/ 104°F). Avoid prolonged heat exposure\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended Usage Rate:\u003c\/strong\u003e 0.01–0.1% HPR (active) in finished formulations. At 10% concentration, use 0.1–1% of this ingredient to achieve 0.01–0.1% active HPR\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003epH:\u003c\/strong\u003e Not pH-dependent (unlike AHAs); stable across a wide pH range\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Oil-soluble; not water-soluble. Use in oil phase or with appropriate solubilizers for emulsions\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePackaging:\u003c\/strong\u003e Use opaque or amber packaging; store away from direct light and heat\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eFormulation Details\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eINCI Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHydroxypinacolone Retinoate\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCAS Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e893412-73-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10% HPR in carrier\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAppearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eClear to pale yellow liquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSolubility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOil-soluble\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eActive Usage Rate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e0.01–0.1% HPR in finished formula\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eIngredient Usage Rate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e0.1–1% of this 10% solution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eIncorporation Phase\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOil phase or cool-down (below 40°C)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003epH Dependency\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eNone — stable across wide pH range\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eShelf Life\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e24 months, properly stored\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eStore at 10–25°C (50–77°F) in opaque\/amber container, away from direct light and heat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eGrade\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCosmetic Grade — External Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch3\u003eSuggested Formulas \u0026amp; Pairings\u003c\/h3\u003e\u003cp\u003eHPR works synergistically with:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNiacinamide\u003c\/strong\u003e — pair with \u003ca href=\"https:\/\/www.pureactivesco.ca\/products\/7903971868771\"\u003eNiacinamide Vitamin B3 Powder\u003c\/a\u003e in the water phase of an emulsion to support barrier function and reduce potential retinoid-related sensitivity; niacinamide and HPR are compatible and complementary\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHyaluronic Acid\u003c\/strong\u003e — add \u003ca href=\"https:\/\/www.pureactivesco.ca\/products\/8001858732131\"\u003eHyaluronic Acid Powder LMW\u003c\/a\u003e to the water phase to counterbalance any dryness associated with retinoid use and boost hydration in the finished formula\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSqualane\u003c\/strong\u003e — dissolve HPR directly in \u003ca href=\"https:\/\/www.pureactivesco.ca\/products\/7629208191075\"\u003eOlive Squalane Oil\u003c\/a\u003e for a clean, minimalist facial oil; squalane is an ideal carrier for HPR due to its skin-identical lipid profile and excellent stability\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreservative\u003c\/strong\u003e — for emulsion systems, protect with \u003ca href=\"https:\/\/www.pureactivesco.ca\/products\/7629188005987\"\u003eEuxyl PE 9010\u003c\/a\u003e at 0.8–1% or \u003ca href=\"https:\/\/www.pureactivesco.ca\/products\/7946666967139\"\u003eGermall Plus\u003c\/a\u003e at 0.1–0.5%\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eExample formula: A 0.05% HPR facial oil — dissolve 0.5% of this 10% HPR solution in Olive Squalane with 0.5% Vitamin E (tocopherol) as antioxidant. Dispense 2–3 drops nightly onto cleansed skin. Begin with 2–3x per week and increase frequency as tolerated.\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAll products sold are cosmetic grade. For external use only. Intended for cosmetic and personal care formulations. Not for use in drug or pharmaceutical products.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Pure Actives Co.","offers":[{"title":"10","offer_id":44259182018659,"sku":null,"price":24.99,"currency_code":"CAD","in_stock":true},{"title":"20","offer_id":44259182051427,"sku":null,"price":44.99,"currency_code":"CAD","in_stock":true},{"title":"50","offer_id":44259182084195,"sku":null,"price":99.99,"currency_code":"CAD","in_stock":true},{"title":"100","offer_id":44259182116963,"sku":null,"price":129.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0598\/4154\/4291\/files\/ChatGPTImageJun15_2026_06_27_41AM.png?v=1781530074","url":"https:\/\/www.pureactivesco.ca\/es\/products\/hydroxypinacolone-retinoate-hpr-10-liquid","provider":"PURE ACTIVES","version":"1.0","type":"link"}